AICAR – 50 mg
Mitochondrial energy activator for fat loss, endurance, and metabolic regulation
Heather
Last Update 10 maanden geleden
Category:
Endurance / Fat Loss / Metabolic Health
Primary Benefits:
Activates AMPK to boost cellular energy and metabolism
Enhances fat burning and glucose uptake
Improves mitochondrial function and endurance capacity
Mimics some effects of physical exercise at the molecular level
Studied for benefits in obesity, insulin resistance, and aging-related fatigue
Mechanism of Action:
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) activates AMPK (AMP-activated protein kinase), a cellular energy sensor that promotes fat oxidation, glucose uptake, and mitochondrial biogenesis. This mimics the metabolic effects of endurance exercise, even in the absence of physical activity. It has been studied for its use in improving metabolic performance and increasing athletic stamina.
Dosing & Protocol:
Subcutaneous (SQ) Injection:
• Reconstitution:
– 50 mg vial → 2.0 ml bacteriostatic water
• Daily Dose:
– 10–25 mg (20–50 units)
• Cycle:
5 days per week
4–6 weeks on, followed by 2–4 weeks off
• Timing:
Take on an empty stomach before bed.
Potential Side Effects:
Fatigue or drowsiness if overdosed
Headache or nausea in sensitive individuals
May lower blood sugar or suppress appetite
Overuse can cause mitochondrial stress or impair gains when stacked with intense weight training (best suited for endurance or fat-loss phases)
Common Stacks:
With 5-Amino-1MQ: For deep mitochondrial and NAD⁺ support
With AOD-9604 or MK-677: To accelerate fat loss or recovery during endurance training
With Metformin or Berberine: For metabolic stacking in insulin resistance support protocols
Notes:
Best taken in the morning to support energy metabolism and avoid fatigue. Avoid use immediately before strength training as it may reduce power output. Store reconstituted peptide in the refrigerator and discard after 30 days. Due to its effects on mitochondrial signaling, cycling is recommended.
Disclaimer:
The information provided in this article is for educational and informational purposes only and is not intended as medical advice. These statements have not been evaluated by the FDA or Health Canada. Peptides and other compounds discussed are intended for research purposes only and are not approved for human consumption unless prescribed by a licensed medical professional. Always consult your healthcare provider before starting any new protocol, supplement, or treatment.