Peptides That Support Nitric Oxide (NO)
Mechanisms, benefits, and protocols for peptides that enhance nitric oxide pathways to improve circulation, performance, and sexual health
Heather
Last Update 7 bulan yang lalu
Category:
Vascular Health / Performance / Sexual Health
Epithalon – 10mg
Benefits & Mechanism:
Epithalon helps restore hormonal and circadian balance, indirectly supporting nitric oxide by reducing oxidative stress and improving endothelial function. Some studies suggest it enhances endothelial nitric oxide synthase (eNOS) activity, which helps maintain vascular tone and circulation.
Dosing & Protocol:
- Reconstitution:
1 ml bacteriostatic water - Daily
Dose: 10 mg (100 units) - Cycle:
Every 3 days for 15 days; repeat twice yearly (5 vials total) - Timing: Morning, on an empty stomach, at least 30 minutes before eating
- Route: Subcutaneous (SQ) injection
GHRP-2 – 5mg / 10mg
Benefits & Mechanism:
GHRP-2 stimulates growth hormone (GH) release, which raises IGF-1 and improves endothelial responsiveness to NO. This results in enhanced vascular tone, circulation, and exercise recovery. GH-related signaling also protects nitric oxide from oxidative degradation.
Dosing & Protocol:
- Reconstitution:
- 5 mg vial → 2 ml
- 10 mg vial → 2 ml
- Daily Dose:
- 5 mg → 166 mcg (10 units)
- 10 mg → 333 mcg (10 units)
- Cycle: 5 days on / 2 days off, 2.5–5 weeks
- Timing: Based on personal preference; no strict time requirement
- Route: Subcutaneous (SQ) injection
Ipamorelin – 2mg / 5mg
Benefits & Mechanism:
Like GHRP-2, Ipamorelin enhances GH secretion but with fewer side effects and a cleaner receptor profile. Increased GH/IGF-1 promotes NO-mediated vasodilation, helping with circulation, recovery, and muscle perfusion during training.
Dosing & Protocol:
- Reconstitution:
- 2 mg vial → 2 ml
- 5 mg vial → 2.5 ml
- Daily Dose:
- 2 mg → 100–200 mcg (10–20 units)
- 5 mg → 200 mcg (10 units)
- Cycle: 5 days on / 2 days off, 4–5 weeks
- Timing: Before bedtime on an empty stomach
- Route: Subcutaneous (SQ) injection
Kisspeptin-10 – 5mg / 10mg
Benefits & Mechanism:
Kisspeptin regulates reproductive hormones via GnRH stimulation, increasing testosterone and estrogen. Both hormones enhance nitric oxide synthase activity in reproductive tissues, supporting erectile function, ovulation, and vascular health.
Dosing & Protocol:
- Reconstitution:
- 5 mg vial → 2 ml
- 10 mg vial → 2 ml
- Daily Dose:
- 5 mg → 250 mcg (5 units)
- 10 mg → 250 mcg (10 units)
- Cycle: 3x per week (Mon/Wed/Fri) for 6.5 weeks
- Timing: Morning on an empty stomach, at least 30 minutes before eating
- Route: Subcutaneous (SQ) injection
MT-2 (Melanotan II) – 10mg
Benefits & Mechanism:
MT-2 activates melanocortin receptors, which stimulate NO release in penile and vaginal tissues, explaining its role in arousal and sexual function. It also improves skin resilience, indirectly protecting NO by reducing oxidative stress.
Dosing & Protocol:
- Reconstitution: 3 ml bacteriostatic water
- Daily Dose: 166 mcg (5 units)
- Cycle: 1–3 times per week for up to 2 weeks, then reduce to once weekly
- Timing: On an empty stomach or with a light meal
- Route: Subcutaneous (SQ) injection
PT-141 – 10mg
Benefits & Mechanism:
PT-141 works through the central melanocortin system to trigger arousal but relies on NO-mediated vasodilation for erection and genital response. Unlike PDE-5 inhibitors, it does not act directly on blood vessels, but enhances NO release through neural signaling.
Dosing & Protocol:
- Reconstitution: 2 ml bacteriostatic water
- Daily Dose: 500 mcg (10 units) → up to 2 mg (40 units)
- Cycle: 3x per week (Mon/Wed/Fri); start at 500 mcg and titrate upward
- Timing: Based on personal preference
- Route: Subcutaneous (SQ) injection
TB-500 – 2mg / 5mg
Benefits & Mechanism:
TB-500 enhances angiogenesis and endothelial repair via upregulation of VEGF and eNOS pathways. This improves microcirculation, tissue oxygenation, and overall NO bioavailability — critical for healing, vascular resilience, and performance.
Dosing & Protocol:
- Reconstitution:
- 2 mg vial → 2 ml
- 5 mg vial → 2.5 ml
- Daily Dose:
- 2 mg → 100–200 mcg (10–20 units)
- 5 mg → 200–400 mcg (10–20 units)
- Cycle: 5 days on / 2 days off, 4–5 weeks
- Timing: Morning, on an empty stomach, at least 30 minutes before eating
- Route: Subcutaneous (SQ) injection
Potential Side Effects (from dosing guide)
- Epithalon: Vivid dreams, mild headache, sleep changes (rare)
- GHRP-2 / Ipamorelin: Water retention, appetite changes, flushing, tingling
- Kisspeptin-10: Headache, flushing, hormonal changes
- MT-2: Nausea, flushing, pigmentation changes (freckles/moles may darken), increased libido
- PT-141: Nausea, headache, flushing, transient blood pressure changes
- TB-500: Mild fatigue, injection-site redness, headache
| Peptide | Mechanism / NO Support | Dosing & Protocol | Cycle | Timing |
| Epithalon – 10mg | Supports eNOS activity, reduces oxidative stress, improves endothelial tone | 10 mg (100 units), reconstituted with 1 ml BAC water, SQ injection | Every 3 days for 15 days; repeat twice yearly | Morning, empty stomach |
| GHRP-2 – 5mg / 10mg | Increases GH/IGF-1, which enhances endothelial NO responsiveness | 5 mg → 166 mcg (10 units); 10 mg → 333 mcg (10 units), SQ injection | 5 days on / 2 off, 2.5–5 weeks | Patient preference (best on empty stomach) |
| Ipamorelin – 2mg / 5mg | GH secretagogue → improves NO-mediated vasodilation and circulation | 2 mg → 100–200 mcg (10–20 units); 5 mg → 200 mcg (10 units), SQ injection | 5 days on / 2 off, 4–5 weeks | Before bedtime, empty stomach |
| Kisspeptin-10 – 5mg / 10mg | Boosts sex hormones (T/E2) → upregulates NOS activity in reproductive tissues | 5 mg → 250 mcg (5 units); 10 mg → 250 mcg (10 units), SQ injection | 3x weekly (Mon/Wed/Fri) for 6.5 weeks | Morning, empty stomach |
| MT-2 – 10mg | Melanocortin activation → NO release in penile/vaginal tissue for arousal | 166 mcg (5 units), SQ injection | 1–3x weekly for 2 weeks, then once weekly | Empty stomach or light meal |
| PT-141 – 10mg | Central melanocortin activation → NO-mediated vasodilation for sexual response | 500 mcg (10 units) → up to 2 mg (40 units), SQ injection | 3x weekly (Mon/Wed/Fri); titrate dose | Patient preference |
| TB-500 – 2mg / 5mg | Enhances angiogenesis & eNOS/VEGF pathways → improves microcirculation | 2 mg → 100–200 mcg (10–20 units); 5 mg → 200–400 mcg (10–20 units), SQ injection | 5 days on / 2 off, 4–5 weeks | Morning, empty stomach |
Suggested Nitric Oxide (NO) Supporting Stacks
- Cardiovascular
health & circulation: Epithalon, TB-500, GHRP-2, Ipamorelin - Exercise
performance & recovery: GHRP-2, Ipamorelin, TB-500 - Sexual function & arousal: PT-141, MT-2, Kisspeptin-10
Notes
- Choose your focus: Use GH secretagogues (GHRP-2, Ipamorelin) for performance/recovery, or PT-141/MT-2/Kisspeptin for sexual health.
- Stacks: TB-500 + GH secretagogue can enhance tissue healing; PT-141 + Kisspeptin may synergize for reproductive function.
- Always follow strict storage and reconstitution guidelines to maintain peptide integrity.
Disclaimer:
This article is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before beginning any peptide or supplement regimen.